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Title: A simple synthesis of 1,3-di-aryl-quinolone derivatives by palladium catalyzed cross-coupling reaction
Authors: Kumar, P Ravi
Shree, A Jaya
Raghavulu, K
Basavaiah, K
Kandula, Venu
Chatterjee, Anindita
Yennam, Satyanarayana
Behera, Manoranjan
Keywords: Enaminone;Suzuki coupling;Natural products;Quinolone;Displacement reaction
Issue Date: Jun-2019
Publisher: NISCAIR-CSIR, India
Abstract: An efficient and novel method for the preparation of N-aryl-quinolone via enaminone synthesis has been described. Subsequent derivatization at 3 position has been accomplished by the palladium catalyzed Suzuki cross coupling reaction. Using this method, various aryl boronic acids as well as hetero aryl boronic acids have been coupled with 3-bromo-quinolone to generate the novel 1,3-di-aryl-quinolone derivatives. The key step quinolone ring formation has been achieved by intramolecular displacement reaction of enaminone 2 with suitably substituted ortho-fluoro group in the aromatic ring.
Page(s): 698-705
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.58B(06) [June 2019]

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