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Title: Raphanus sativus (Linn.) fresh juice priming moderates sucrose-induced postprandial glycemia as well as postprandial glycemic excursion in rats
Authors: Srujana, Medikonda Soma
Thota, Ram Sai Prabhath
Anand, Ajay
Anusha, Komati
Zehra, Amtul
Prasad, Konduri
Babu, Katragadda Suresh
Tiwari, Ashok Kumar
Keywords: Antioxidant activity;α-Glucosidase inhibition;Postprandial glycemic excursion;Postprandial hyperglycemia;Raphanus sativus
Issue Date: Apr-2019
Publisher: NISCAIR-CSIR, India
IPC Code: Int. Cl.19: A61P 17/18, C12P 19/16, A61K 38/28, A61K 38/28, A61K 36/00
Abstract: Consumption of sugar sweetened beverages increase individual’s susceptibility towards weight gain, development of Type 2 diabetes mellitus, hypertension, cardiovascular disorders and number of chronic illnesses. Extended postprandial hyperglycemic rise and larger postprandial glycemic spikes following sugar ingestion in diabetic as well as non-diabetic individuals relate with the onset of cardiovascular complications and development of atherosclerosis. Oxidative stress induced due to prolonged postprandial hyperglycemia further aggravates development of diabetic complications. Influence of Raphanus sativus leaf and root juice on sucrose induced postprandial glycemic rise and postprandial glycemic spikes in rats was evaluated in this research. It was observed that priming rats with R. sativus leaf and root juice assuaged sucrose induced postprandial glycemic rise and postprandial glycemic excursions. The juice of R. sativus leaf was found superior than root juice in achieving these results. Similarly, the juice of leaves was more potent (p<0.01) in decreasing sucrose induced postprandial glycemic load than the juice of root. Acidic in nature, juice of R. sativus leaf and root was rich source of polyphenol, flavonoid and displayed potent free radical scavenging activity. Additionally, juices also mitigated formation of advance glycation end-products and glycation of hemoglobin under hyperglycemic environment.
Page(s): 339-345
ISSN: 0975-1068 (Online); 0972-5938 (Print)
Appears in Collections:IJTK Vol.18(2) [April 2019]

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