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dc.contributor.authorVijayendar, Venepally-
dc.contributor.authorKrishna, E Vamshi-
dc.contributor.authorMisra, Sunil-
dc.contributor.authorJala, Ram Chandra Reddy-
dc.identifier.issn0975-0983(Online); 0376-4699(Print)-
dc.description.abstractIn an attempt to find a new class of cytotoxic agents, a series of 3,6-disubstituted-[1,2,4] triazolo[3,4-b] [1,3,4]thiadiazoles have been synthesized using undecenoic acid and various cinnamic acids. The structures of the synthesized compounds have been confirmed using 1H and 13C NMR, IR and mass spectroscopy. The prepared compounds have been evaluated for their in vitro cytotoxic activities against four human cancer cell lines namely, HeLa, B16-F10, SKOV3, MCF7 and CHO-K1 Normal Cell line using MTT assay. Compounds 6a and 6h show promising activity against HeLa (IC50 value 8.92µM) and SKOV3 cell lines (IC50 value 9.43 µM). Majority of the compounds show significant activities against HeLa cell line with the IC50 values ranging from 8.92 to 13.44 μM. All the compounds show good activity against SKOV3 cell line with the IC50 values ranging from 9.43 to 19.34 μM. Majority of the compounds are non toxic towards the Chinese hamster ovary (CHO-K1) normal cell line.en_US
dc.publisherNISCAIR-CSIR, Indiaen_US
dc.rights CC Attribution-Noncommercial-No Derivative Works 2.5 Indiaen_US
dc.sourceIJC-B Vol.58B(04) [April 2019]en_US
dc.subjectUndecenoic aciden_US
dc.subjectCinnamic acidsen_US
dc.subjectCancer cell lineen_US
dc.titleSynthesis, cytotoxic evaluation of substituted cinnamic-based 1,2,4-triazolo thiadiazolesen_US
Appears in Collections:IJC-B Vol.58B(04) [April 2019]

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