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dc.contributor.authorPrasad, Suchita-
dc.contributor.authorMittal, Ayushi-
dc.contributor.authorSharma, Sunil K-
dc.identifier.issn0975-0983(Online); 0376-4699(Print)-
dc.description.abstractA series of fourteen pyranochromen-2-one acrylate derivatives has been synthesized by acid-catalyzed esterification reaction of the corresponding pyranochromen-2-one acrylic acids with various alcohols under reflux conditions. In order to have comparison of the activity profiles of esters and amides, the synthesis of ten pyranochromen-2-one acrylamides from corresponding acrylic acids using different coupling agents has also been carried out. All of the synthesized compounds have been fully characterized from their spectral data and evaluated for antibacterial activity against both Gram-positive (Bacillus cereus and Staphylococcus aureus) and Gram-negative bacteria (Pseudomonas aeruginosa and Escherichia coli). It is inferred form the results that the presence of hydroxyl group along with longer hydrophobic alkyl chain is favorable for a compound to inhibit bacterial growth, which can be used to design and develop the next generation of compounds with higher antibacterial efficacy.en_US
dc.publisherNISCAIR-CSIR, Indiaen_US
dc.rights CC Attribution-Noncommercial-No Derivative Works 2.5 Indiaen_US
dc.sourceIJC-B Vol.58B(04) [April 2019]en_US
dc.subjectAntibacterial activityen_US
dc.subjectGram positiveen_US
dc.subjectGram negativeen_US
dc.titleSynthesis of novel acrylyl pyranochromen-2-one derivatives and their antibacterial activity evaluationen_US
Appears in Collections:IJC-B Vol.58B(04) [April 2019]

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