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Title: Synthesis, characterization and antibacterial screening of fluorinated benzofuran containing heterocycles
Authors: Kundlikar, S G
Randhavane, P V
Akolkar, H N
Karale, B K
Keywords: Benzofuran;Chromones;Pyrazoles;Antibacterial activity
Issue Date: Apr-2019
Publisher: NISCAIR-CSIR, India
Abstract: 2-(4-Fluorophenyl)-5-phenylbenzofuran-3-carboxylic acid 1 when treated with substituted 2-hydroxyacetophenones 2 in dry pyridine and POCl3 affords compound 3 which when reacted with pyridine/KOH by B. V. transformation gives 4. Compound 4 on refluxing with different reagents Ac2O in presence of sodium acetate, acetic acid in HCl, and hydrazinehydrate in alcohol gives 5, 6 and 7 respectively. The structures of all synthesized compounds have been confirmed by spectroscopic techniques. All the synthesized compounds have been screened for their antibacterial activity.
Page(s): 504-510
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.58B(04) [April 2019]

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