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Title: Hepatic histopathology in Oreochromis mossambicus (Peters, 1852) under silica nanoparticles toxicity
Authors: Vidya, PV
Asifa, KP
Chitra, KC
Keywords: Aquatic pollution;Liver toxicity;Mozambique tilapia
Issue Date: Apr-2019
Publisher: NISCAIR-CSIR, India
Abstract: Silica (SiO2) nanoparticles are well known for their biomedical and biotechnological applications. Now that, the demand has pushed nano silica to be a cause of concern, particularly its biosafety impact, as emulsions or suspensions it can easily enter into the gills of aquatic fishes. In this context, studies on pathological effects of nanoparticles gains significance. Here, we exposed freshwater fish, Oreochromis mossambicus to silica nanoparticles (SiO2-NPs) at 5 mg/L for 24, 48 and 96 h and observed the histopathological changes in the liver tissues. Exposure to nanoparticles for 24 h showed disorganized hepatic parenchyma with mild vacuolization when compared to control hepatocytes. At 48 h of exposure, vacuolization and disintegrated nucleus were noted, and at 96 h, it showed cytoplasmic vacuolization and leukocyte infiltration. The severity of hepatic lesions was observed to be increased in time-dependent manner.
Page(s): 293-296
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Appears in Collections:IJEB Vol.57(04) [April 2019]

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