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Title: Simultaneous kinetic determination of paracetamol and caffeine using Cu(II)-neocuproine in presence of dodecyl sulfate by H-point standard addition method
Authors: Tavallali, H
Sheikhaei, M
Keywords: Analytical chemistry;Spectrophotometry;H-point standard addition;Paracetamol;Caffeine;Neocuproine
Issue Date: Jun-2009
Publisher: CSIR
IPC Code: Int Cl.8 G01N21/25
Abstract: A simple, feasible and selective kinetic spectrophotometric method for simultaneous determination of paracetamol and caffeine using H-point standard addition method is described. The method is based on difference in the rate of oxidation of the compounds with Cu(II)-neocuproine system and formation of Cu(I)–neocuproine complex, which is monitored at 453 nm and at pH 5.0 in the presence of sodium dodecyl sulfate. Experimental conditions such as pH, reagents concentrations, ionic strength and temperature have been optimized. Paracetamol and caffeine can be determined in the range 1.5-7.0 and 0.1-3.0 μg ml-1 respectively. The proposed method has been applied for the determination of paracetamol and caffeine in pharmaceutical samples with satisfactory results.
Page(s): 812-816
ISSN: O975-0975 (Online); 0376-4710 (Print)
Appears in Collections:IJC-A Vol.48A(06) [June 2009]

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