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|Title:||Simultaneous kinetic determination of paracetamol and caffeine using Cu(II)-neocuproine in presence of dodecyl sulfate by H-point standard addition method|
H-point standard addition
|Series/Report no.:||Int Cl.<sup>8</sup> G01N21/25|
|Abstract:||A simple, feasible and selective kinetic spectrophotometric method for simultaneous determination of paracetamol and caffeine using H-point standard addition method is described. The method is based on difference in the rate of oxidation of the compounds with Cu(II)-neocuproine system and formation of Cu(I)–neocuproine complex, which is monitored at 453 nm and at <i style="">p</i>H 5.0 in the presence of sodium dodecyl sulfate. Experimental conditions such as <i style="">p</i>H, reagents concentrations, ionic strength and temperature have been optimized. Paracetamol and caffeine can be determined in the range 1.5-7.0 and 0.1-3.0 μg ml<sup>-1 </sup>respectively. The proposed method has been applied for the determination of paracetamol and caffeine in pharmaceutical samples with satisfactory results.|
|ISSN:||O975-0975 (Online); 0376-4710 (Print)|
|Appears in Collections:||IJC-A Vol.48A(06) [June 2009]|
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