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Title: Thermodynamics of transfer of amino acids from water to ethanol-water mixtures
Authors: Jahagirdar, D V
Arbad, B R
Chondhekar, T K
Pankanti, (Miss) S U
Issue Date: Apr-1989
Publisher: NISCAIR-CSIR, India
Abstract: Dissociation constants of -tryptophan, -histidine, -aspartic acid, -glutamic acid and t-serine have been determined in water and ethanol-water mixtures at 298 K potentiometrically by the Calvin-Bjerrum titration technique. These values have been used to calculate the free energies of transfer G(i) involved in the dissociation equilibria. G (RH) and G(R2-) have been calculated (RH±) being the zwitter ion) knowing the solubilities of these acids in ethanol-water mixtures. Contribution due to amino acid side chain to the free energy of transfer from 100% ethanol to water has been estimated in acidic, neutral and basic media. The equivalence of these values confirms the hydrophobicity scale first proposed by Nozaki and Tanford [J bioi Chem, 246 (1971) 2211].
Page(s): 366-370
ISSN: 0975-0975(Online); 0376-4710(Print)
Appears in Collections:IJC-A Vol.28A(05) [May 1989]

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