NISCAIR Online Periodicals Repository

Research Journals >
Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.46 [2008] >
IJEB Vol.46(12) [December 2008] >

Title: Effect of dietary iron overload in rat brain: Oxidative stress, neurotransmitter level and serum metal ion in relation to neurodegenerative disorders
Authors: Elseweidy, Mohamed M
El-Baky, Atef E Abd
Keywords: Chromium
Ferrous sulphate
Issue Date: Dec-2008
Publisher: CSIR
Abstract: Excess iron causes cell injury by reacting with superoxide anions (O2) and hydrogen peroxide (H2O2) and producing hydroxyl radical (OH) and reactive oxygen species (ROS). In the present study, albino rats were fed with biscuits enriched with ferrous sulphate (0.3% w/w) for 10 weeks to have overload iron conditions and observed a significant decrease in serum chromium, brain serotonin and dopamine, while iron and zinc increased significantly in serum. Increasing iron level might be responsible for accelerated dopamine oxidation with subsequent quinone formation.
Page(s): 855-858
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Source:IJEB Vol.46(12) [December 2008]

Files in This Item:

File Description SizeFormat
IJEB 46(12) 855-858.pdf130.78 kBAdobe PDFView/Open
 Current Page Visits: 132 
Recommend this item


Online Submission of Articles |  NISCAIR Website |  National Knowledge Resources Consortium |  Contact us |  Feedback

Disclaimer: NISCAIR assumes no responsibility for the statements and opinions advanced by contributors. The editorial staff in its work of examining papers received for publication is helped, in an honorary capacity, by many distinguished engineers and scientists.

CC License Except where otherwise noted, the Articles on this site are licensed under Creative Commons License: CC Attribution-Noncommercial-No Derivative Works 2.5 India

Copyright © 2015 The Council of Scientific and Industrial Research, New Delhi. All rights reserved.

Powered by DSpace Copyright © 2002-2007 MIT and Hewlett-Packard | Compliant to OAI-PMH V 2.0

Home Page Total Visits: 164476 since 01-Sep-2015  Last updated on 21-Jun-2016Webmaster: