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Title: Synthesis of N-(3′,5′-dimethyl- 4′-hydroxybenzyl)- N-tosyl-3,4-dimethoxybenzyl amine
Authors: Raju, B China
Neelakantan, Parvathi
Bhalerao, U T
Keywords: N-(3′,5′-dimethyl-4′-hydroxybenzyl)-N-tosyl-3,4-di¬¬¬me¬thoxybenzyl amine;Isoindolines
Issue Date: Jan-2007
Publisher: CSIR
IPC Code: Int. Cl.⁸ C07C
Abstract: Reaction of 4-benzyloxy-3,5-dimethyl benzyl bromide 4 and N-tosyl-3,4-dimethoxy benzyl amine 5 gives the N-(4′-benzyloxy-3′,5′-dimethylbenzyl)-N-tosyl-3,4-dimethoxybenzyl amine 6. The obtained product on debenzylation affords N-(3′,5′-dimethyl-4′-hydroxybenzyl)-N-tosyl-3,4-dimethoxybenzyl amine 7 in 94% yield, which is key intermediate in the synthesis of isoindolines.
Page(s): 201-203
ISSN: 0376-4699
Appears in Collections:IJC-B Vol.46B(01) [January 2007]

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