NISCAIR Online Periodicals Repository

Research Journals >
Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.46 [2008] >
IJEB Vol.46(12) [December 2008] >

Title: Anti-Salmonella activity of Terminalia belerica: In vitro and in vivo studies
Authors: Madani, A
Jain, S K
Keywords: Anti-Salmonella activity
T. belerica
Issue Date: Dec-2008
Publisher: CSIR
Abstract: To search for an herbal remedy for protection against and treatment for typhoid fever, a number of plants were screened. Anti-Salmonella activity of Terminalia belerica, an ingredient of Ayurvedic preparation ‘triphala’ used for treatment of digestive and liver disorders, has been reported. Fruits of T. belerica were extracted with petroleum ether, chloroform, acetone, alcohol and water and efficacy of extracts against Salmonella typhi and Salmonella typhimurium was evaluated. Alcoholic and water extracts of T. belerica showed significant anti-Salmonella activity and MIC was 12.5 mg/ml against S. typhimurium. Aqueous extracts of Picrohiza kurroa and Vitits vinefera also showed low anti-Salmonella activity where as aqueous extracts of Asparagus racemosus and Zingiber officinale showed no anti-Salmonella activity. Extracts of T. belerica, Picrohiza kurroa and Vitits vinefera with other solvents such as chloroform and petroleum ether showed insignificant activity. Results showed that aqueous extract of T. belerica was bactericidal at high concentrations where as low concentrations showed bacteriostatic property. In vitro cellular toxicity studies showed no cyto-toxicity associated with T. belerica extracts. Pretreatment of mice with aqueous extract of T. belerica conferred protection against experimental Salmonellosis and 100% survival of animals has been reported when challenged with lethal doses of S. typhimurium.
Page(s): 817-821
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Source:IJEB Vol.46(12) [December 2008]

Files in This Item:

File Description SizeFormat
IJEB 46(12) 817-821.pdf155.98 kBAdobe PDFView/Open
 Current Page Visits: 164 
Recommend this item


Online Submission of Articles |  NISCAIR Website |  National Knowledge Resources Consortium |  Contact us |  Feedback

Disclaimer: NISCAIR assumes no responsibility for the statements and opinions advanced by contributors. The editorial staff in its work of examining papers received for publication is helped, in an honorary capacity, by many distinguished engineers and scientists.

CC License Except where otherwise noted, the Articles on this site are licensed under Creative Commons License: CC Attribution-Noncommercial-No Derivative Works 2.5 India

Copyright © 2015 The Council of Scientific and Industrial Research, New Delhi. All rights reserved.

Powered by DSpace Copyright © 2002-2007 MIT and Hewlett-Packard | Compliant to OAI-PMH V 2.0

Home Page Total Visits: 163035 since 01-Sep-2015  Last updated on 21-Jun-2016Webmaster: