NISCAIR Online Periodicals Repository

Research Journals >
Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.46 [2008] >
IJEB Vol.46(12) [December 2008] >

Title: Central nervous system activity of acute administration of ethanol extract of Punica granatum L. seeds in mice
Authors: Kumar, Sokindra
Maheshwari, Kamal Kishore
Singh, Vijender
Keywords: Antioxidant
Punica granatum
Issue Date: Dec-2008
Publisher: CSIR
Abstract: Role of ethanolic extract of P. granatum seeds on central nervous system (CNS) in animal models of elevated plus maze test, barbiturate-induced sleeping time, tail suspension test, hot-plate and tail-flick test was studied. P. granatum (PG) extract was administered to young and aged mice at single doses of 100, 250 and 500 mg/kg, perorally while diazepam (1 mg/kg), morphine (5 mg/kg) and imipramine (30 mg/kg) were used intraperitoneally as standard drugs. The results showed that PG extract at all dose levels significantly exhibited the anxiolytic activity. In another study PG extract (250 and 500 mg/kg) significantly increased the sleeping latency and reduced the sleeping time. Tail suspension test showed that PG extract (250 and 500 mg/kg) was able to induce a significant decrease in the immobility time, similar to imipramine, a recognized antidepressant drug. Tail-flick and hot-plate tests exhibited antinociceptive property of PG extract, similar to morphine, a recognized antinociceptive agent. Phytochemical investigation of ethanol extract for the presence of phenolic compounds, flavonoids, tannins, anthocyanins, sugars and saponins was also carried out. Phytochemical screening and measurement of reducing power revealed the CNS activity of ethanol extract of PG seeds may be due to its antioxidative profile.
Page(s): 811-816
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Source:IJEB Vol.46(12) [December 2008]

Files in This Item:

File Description SizeFormat
IJEB 46(12) 811-816.pdf130.42 kBAdobe PDFView/Open
 Current Page Visits: 123 
Recommend this item


Online Submission of Articles |  NISCAIR Website |  National Knowledge Resources Consortium |  Contact us |  Feedback

Disclaimer: NISCAIR assumes no responsibility for the statements and opinions advanced by contributors. The editorial staff in its work of examining papers received for publication is helped, in an honorary capacity, by many distinguished engineers and scientists.

CC License Except where otherwise noted, the Articles on this site are licensed under Creative Commons License: CC Attribution-Noncommercial-No Derivative Works 2.5 India

Copyright © 2015 The Council of Scientific and Industrial Research, New Delhi. All rights reserved.

Powered by DSpace Copyright © 2002-2007 MIT and Hewlett-Packard | Compliant to OAI-PMH V 2.0

Home Page Total Visits: 161968 since 01-Sep-2015  Last updated on 21-Jun-2016Webmaster: