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Title: Synthesis and spectrum of new Schiff bases as polydentate ligands and potential antibacterial reagents
Authors: Cai, Li-Hua
Hu, Pei-Zhi
Du, Xiao-Lan
Zhang, Li-Xia
Liu, Yi
Keywords: Schiff base;Polydentate ligands;Antibacterial reagents;Pyridinedicarboxylic;Diamide;Aldehyde
Issue Date: Mar-2007
Publisher: CSIR
IPC Code: Int.Cl.⁸ C07D
Abstract: Eight novel linear polydentate Schiff base ligands, N,N′-bis(R-iminoethyl)-2,6-pyridinedicarboxylic diamide (IIa-g), where R=2,4-dihydroxyphenyl, 2,4-dimethoxyphenyl, furanyl, thiophenic, 2-pyridinyl, 3-pyridinyl, 4-pyridinyl and N,N′-bis(2,4-dihydroxyphenyliminopropyl)-2,6-pyridinedicarboxylic diamide (IIh) have been synthesized by the reaction of Ia (Ib) with various aldehydes. The compounds are characterized by elemental analysis, IR, UV-Vis, LIF, MS and ¹H NMR. Analyzing their MS spectra found that the ⍺-fragmentation of imine is the main fragmentation pattern. In addition, microcalorimetric test of the inhibitory capacities of these compounds on E. coli and S. aureus show that they have antibacterial activity to different extent.
Page(s): 523-528
ISSN: 0376-4699
Appears in Collections:IJC-B Vol.46B(03) [March 2007]

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