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|Title:||Screening of natural phenolic compounds for potential to inhibit bacterial cell division protein FtsZ|
<i style="">Trans</i>-cinnamic acid
|Abstract:||FtsZ plays an important role in bacterial cell division by polymerizing to form the Z ring at the site of cytokinesis. Phytochemicals are known to disrupt bacterial cell division through inhibition of FtsZ assembly. In the present study phytochemicals like eugenol, <i style="">trans-</i>cinnamic acid, 4-formyl cinnamic acid, naringenin and caffeic acid were were tested for their potential to inhibit cell division. Effect of these antimicrobial compounds on the growth of <i style="">E. coli</i> was determined and the inhibition of FtsZ assembly <i style="">in vitro</i> was investigated. The present study revealed <i style="">trans</i>-cinnamic acid as the most potent inhibitor of FtsZ assembly.|
|ISSN:||0975-1009 (Online); 0019-5189 (Print)|
|Appears in Collections:||IJEB Vol.46(11) [November 2008]|
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