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Title: Screening of natural phenolic compounds for potential to inhibit bacterial cell division protein FtsZ
Authors: Rastogi, Neerja
Domadia, Prerna
Shetty, Sangeeta
Dasgupta, Debjani
Keywords: Caffeic acid
<i style="">Trans</i>-cinnamic acid
Issue Date: Nov-2008
Publisher: CSIR
Abstract: FtsZ plays an important role in bacterial cell division by polymerizing to form the Z ring at the site of cytokinesis. Phytochemicals are known to disrupt bacterial cell division through inhibition of FtsZ assembly. In the present study phytochemicals like eugenol, <i style="">trans-</i>cinnamic acid, 4-formyl cinnamic acid, naringenin and caffeic acid were were tested for their potential to inhibit cell division. Effect of these antimicrobial compounds on the growth of <i style="">E. coli</i> was determined and the inhibition of FtsZ assembly <i style="">in vitro</i> was investigated. The present study revealed <i style="">trans</i>-cinnamic acid as the most potent inhibitor of FtsZ assembly.
Description: 783-787
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Appears in Collections:IJEB Vol.46(11) [November 2008]

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