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Title: Screening of natural phenolic compounds for potential to inhibit bacterial cell division protein FtsZ
Authors: Rastogi, Neerja
Domadia, Prerna
Shetty, Sangeeta
Dasgupta, Debjani
Keywords: Caffeic acid;Cytokinesis;Eugenol;FtsZ;Trans-cinnamic acid
Issue Date: Nov-2008
Publisher: CSIR
Abstract: FtsZ plays an important role in bacterial cell division by polymerizing to form the Z ring at the site of cytokinesis. Phytochemicals are known to disrupt bacterial cell division through inhibition of FtsZ assembly. In the present study phytochemicals like eugenol, trans-cinnamic acid, 4-formyl cinnamic acid, naringenin and caffeic acid were were tested for their potential to inhibit cell division. Effect of these antimicrobial compounds on the growth of E. coli was determined and the inhibition of FtsZ assembly in vitro was investigated. The present study revealed trans-cinnamic acid as the most potent inhibitor of FtsZ assembly.
Page(s): 783-787
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Appears in Collections:IJEB Vol.46(11) [November 2008]

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