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Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.46 [2008] >
IJEB Vol.46(11) [November 2008] >
| Title: | Screening of natural phenolic compounds for potential to inhibit bacterial cell division protein FtsZ |
| Authors: | Rastogi, Neerja
Domadia, Prerna
Shetty, Sangeeta
Dasgupta, Debjani |
| Keywords: | Caffeic acid
Cytokinesis
Eugenol
FtsZ
Trans-cinnamic acid |
| Issue Date: | Nov-2008 |
| Publisher: | CSIR |
| Abstract: | FtsZ plays an important role in bacterial cell division by polymerizing to form the Z ring at the site of cytokinesis. Phytochemicals are known to disrupt bacterial cell division through inhibition of FtsZ assembly. In the present study phytochemicals like eugenol, trans-cinnamic acid, 4-formyl cinnamic acid, naringenin and caffeic acid were were tested for their potential to inhibit cell division. Effect of these antimicrobial compounds on the growth of E. coli was determined and the inhibition of FtsZ assembly in vitro was investigated. The present study revealed trans-cinnamic acid as the most potent inhibitor of FtsZ assembly. |
| Page(s): | 783-787 |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.46(11) [November 2008]
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