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Title: Wound healing activity of <i>Sesamum indicum </i>L seed and oil in rats
Authors: Kiran, Kotade
Asad, Mohammed
Keywords: Burn wound
Dead space wound
Excision wound
Incision wound
<i>Sesamum indicum </i>L
Issue Date: Nov-2008
Publisher: CSIR
Abstract: The seeds of <i>S. indicum</i> L (Pedaliaceae) are used traditionally in the folklore for the treatment of various kinds of wounds. The present study was undertaken to verify the effect of <i>S. indicum</i> seeds and its oil<i> </i>on experimentally induced excision wound, incision wound, burn wound and dead space wound models in rats. <i>Aloe vera </i>was used as standard wound healing agent. A formulation of seeds and oil was prepared in carbopol at 2.5% and 5% concentrations and applied to the wounds. In the excision and burn wound models, the so treated animals showed significant reduction in period of epithelization and wound contraction (50%). In the incision wound model a significant increase in the breaking strength was observed. Seeds and oil<i> </i>treatment (250 mg and 500 mg/kg; po) in dead space wound model, produced a significant increase in the breaking strength, dry weight and hydroxyproline content of the granulation tissue. The results suggest that <i>S. indicum </i>seeds and oil<i> </i>applied topically or administered orally possesses wound healing activity.
Description: 777-782
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Appears in Collections:IJEB Vol.46(11) [November 2008]

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