Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/4637
Title: Dose-dependent response of central dopaminergic systems to buspirone in mice
Authors: Jadhav, S A
Gaikwad, R V
Gaonkar, R K
Thorat, V M
Gursale, S C
Balsara, J J
Keywords: Apomorphine
Buspirone
Cage climbing behaviour
Catalepsy
Haloperidol
Methamphetamine
Mice
Serotonergic system
Stereotypy
Issue Date: Oct-2008
Publisher: CSIR
Abstract: Buspirone, a partial agonist of 5-hydroxytryptamine<sub>1A </sub>autoreceptors, preferentially blocks the presynaptic rather than the postsynaptic D<sub>2</sub> dopamine (DA) receptors. Behavioural effects of a wide dose range of buspirone were therefore studied in mice. Buspirone at 0.625 to 5 mg/kg ip induced stereotyped cage climbing behaviour which was antagonized by pretreatment with haloperidol, alpha-methyl-<i style="">p</i>-tyrosine and small doses of apomorphine. Buspirone at 10, 20 and 40 mg/kg ip induced catalepsy and antagonized oral stereotypies induced by high doses of apomorphine and methamphetamine and apomorphine-induced cage climbing behaviour. The findings indicate that buspirone at 0.625 to 5 mg/kg selectively blocks the presynaptic mesolimbic D<sub>2</sub> DA autoreceptors and releases DA which stimulates the postsynaptic mesolimbic D<sub>2</sub> and D<sub>1</sub> DA receptors and induces cage climbing behaviour. Buspirone, at 10, 20 and 40 mg/kg blocks the postsynaptic striatal and mesolimbic D<sub>2</sub> and D<sub>1</sub> DA receptors. Pretreatment with l-tryptophan, dexfenfluramine and fluoxetine antagonized buspirone induced cage climbing behaviour and potentiated buspirone induced catalepsy. Pretreatment with trazodone, mianserin and <i style="">p</i>-chlorophenylalanine potentiated buspirone induced cage climbing behaviour and antagonized buspirone induced catalepsy. The results indicate that drugs which influence the activity of central serotonergic systems modulate the intensity of buspirone induced cage climbing behaviour and catalepsy.
Description: 704-714
URI: http://hdl.handle.net/123456789/4637
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Appears in Collections:IJEB Vol.46(10) [October 2008]

Files in This Item:
File Description SizeFormat 
IJEB 46(10) 704-714.pdf144.25 kBAdobe PDFView/Open


Items in NOPR are protected by copyright, with all rights reserved, unless otherwise indicated.