Please use this identifier to cite or link to this item:
|Title:||Distribution of heparinoid-active sulphated polysaccharides in some Indian marine green algae|
Ramavat, B. K.
Mody, K. H.
Oza, R. M.
|Abstract:||Sixteen species of Indian marine green algae belonging to the genus <i style="">Caulerpa,. Cladophora, Bryopsis, Boodlea, Chaetomorpha, Ulva, Enteromorpha</i> and<i style=""> Valoniopsis</i> were screened for blood anticoagulant activity. Cold and hot water sulphated polysaccharides extracts were prepared, their chemical constituents i.e. sulphate, sugar, protein and uronic acids were estimated and molecular weight (MW) range was determined. Blood anticoagulant activity was evaluated by prothrombine time (PT) test. It was found that activity was associated with sugar and sulphate contents and MW. Extracts possessing comparatively high molecular weight (12-14 x 10<sup>5</sup>) with higher sugar (≥ 20%) and sulphate (<img src='/image/spc_char/wave.gif'> 8%)<i style=""> </i>and lower protein (<img src='/image/spc_char/wave.gif'> 12%) and low uronic acid (<img src='/image/spc_char/wave.gif'> 2%) contents showed maximum activity. Species of <i style="">Caulerpa </i>exhibited highest activity which is comparable to heparin i.e. they contained 93-151 heparin units/mg (IU/mg), species of <i style="">Ulva </i>and<i style=""> Enteromorpha</i> showed feeble activity (<img src='/image/spc_char/wave.gif'>6.0 IU/mg) and all other species had moderate activity with <img src='/image/spc_char/wave.gif'>60IU/mg. Thus, SPS isolated from different Chlorophycean algae had different chemical composition, MW range and blood anticoagulant activity which were comparable within species level, but those differed in degrees from one genus to another.|
|ISSN:||0975-1033 (Online); 0379-5136 (Print)|
|Appears in Collections:||IJMS Vol.30(4) [December 2001]|
Items in NOPR are protected by copyright, with all rights reserved, unless otherwise indicated.