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Title: Synthesis, characterization and cytotoxicity of (3,4-diaminobenzoic acid)- haloplatinum(II)/palladium(II)
Authors: Jain, N
Srivastava, T S
Issue Date: Feb-1992
Publisher: NISCAIR-CSIR, India
Abstract: The synthesis of platinum compounds of the type [Pt (daba) X2](where daba = 3,4-diaminobenzoic acid and X = Cl, Br, or I) and the analogous chloro and bromo compounds of Pd(II) has been carried out. These compounds have been characterized by molar conductance measurements, electronic absorption, and infrared, 1H NMR and X-ray photoelectron spectroscopy. The complexes are non-electrolytic in nature and have square planar geometry with two coordination positions occupied by two amino groups of 3,4- diaminobenzoic acid and remaining two positions occupied by halide ions. The sodium salts of the above compounds have been tested against P388 lymphocytic leukemia cells. [Pt(daba)Cl2] and Pt(daba)Br2l have I.D.50 ovalues less than that of cisplatin and [Pt(daba)I2] has I.D50 values comparable to that of cisplatin.
Page(s): 102-105
ISSN: 0975-0975(Online); 0376-4710(Print)
Appears in Collections:IJC-A Vol.31A(02) [February 1992]

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