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Title: Root exudates of wheat seedlings express antibacterial and antioxidant activity and stimulate proliferation of liver cells
Authors: Kuznetsova, Yu A
Bozhkov, A I
Menzyanova, N G
Goltvyansky, A V
Azeez, Zaid Ali
Keywords: Antibacterial;Antioxidant activity;Green microalgae;Liver regeneration;Root exudates wheat
Issue Date: Dec-2018
Publisher: NISCAIR-CSIR, India
IPC Code: Int. cl. (2015.01)-A61K 36/00, A61P 31/00, A61P 39/00
Abstract: Root exudates (REs) of wheat seedlings were investigated for antioxidant, algecidic, antibacterial activity, as well as their influence on the proliferative activity of liver cells on the model of partial hepatectomy was studied. REs were obtained from 1-3-day-old wheat seedlings growing in aquatic culture. The RE of 1-3-day old wheat seedlings showed pronounced antioxidant and anti-radical activity in an in vitro system that was comparable to the activity of known antioxidants, such as tocopherol and free-radical scavenger - ethanol. RE of wheat seedlings had antibacterial activity against pathogens such as Staphyloococcus aureus and Streptococcus pyogens, while they stimulated the growth of nodule bacteria Rhizobium leguminosarum. The administration of RE in different concentrations into the microalgae culture medium of Dunaliella viridis showed a U-stimulatory effect on its growth, at a concentration of 0.1-1%, it was increased by 50-57% compared to the control. However, these concentrations of wheat seedlings RE did not affect the growth rate of Chlorella vulgaris microalgae and Spirulina platensis cyanobacteria. Intraperitoneal injection of modified RE at a dose of 0.1 mg to 1 mg / 100 g of body weight of rats after removal of 2/3 of the liver mass (partial hepatectomy) led to an increase in the rate of DNA synthesis by of 7-8 and RNA synthesis by 3-4 times compared to control.
Page(s): 303-310
ISSN: 0976-0512 (Online); 0976-0504 (Print)
Appears in Collections:IJNPR Vol.9(4) [December 2018]

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