Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/4586
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dc.contributor.authorSrimani, Phalguni-
dc.contributor.authorMandal, Goutam-
dc.contributor.authorGanguly, Sudipto-
dc.contributor.authorSaha, Piu-
dc.contributor.authorSen, Rupashree-
dc.contributor.authorDe, Rajib-
dc.contributor.authorChatterjee, Arnab-
dc.contributor.authorBhattacharyya, Maitrayee-
dc.contributor.authorChaudhuri, Utpal-
dc.contributor.authorBandyopadhyay, Susanta K-
dc.contributor.authorChatterjee, Mitali-
dc.date.accessioned2009-06-15T12:05:54Z-
dc.date.available2009-06-15T12:05:54Z-
dc.date.issued2009-06-
dc.identifier.issn0975-0959 (Online); 0301-1208 (Print)-
dc.identifier.urihttp://hdl.handle.net/123456789/4586-
dc.description241-246en_US
dc.description.abstractHbE-beta thalassemia is caused by an interaction between HbE and defective b globin gene of thalassemia. Repeated blood transfusions cause an iron overload, triggering an enhanced generation of free radicals. In the present study, the anti-oxidant property of ethanolic extract of the leaves of Piper betle Linn. (PB) was evaluated in the erythrocytes from patients with HbE-beta thalassemia. In patients with HbE-beta thalassemia (n = 30) and age- and sex-matched healthy individuals (n = 30), the baseline level of reactive oxygen species (ROS) and free radical scavenging activity in the erythrocytes was measured by flow cytometry using dihydrodichlorofluorescein diacetate (H2DCFDA), in terms of the geometric mean fluorescence channel (GMFC). The baseline generation of ROS was significantly higher in the erythrocytes from patients with HbE-beta thalassemia, as compared to healthy volunteers, the GMFC being 67.20 ± 4.64 vs. 23.03 ± 1.88 (p<0.001), which was effectively decreased by PB. Similarly, H2O2 (0.5-1.0 mM) induced a higher increase in the GMFC in the erythrocytes from patients with HbE-beta thalassemia, as compared to controls which was effectively reduced by PB. Taken together, PB showed promising anti-oxidant activity against the erythrocytes from patients with HbE-beta thalassemia.en_US
dc.language.isoen_USen_US
dc.publisherCSIRen_US
dc.sourceIJBB Vol.46(3) [June 2009]en_US
dc.subjectHbE beta thalassemiaen_US
dc.subjectReactive oxygen species (ROS)en_US
dc.subjectPiper betle Linnen_US
dc.subjectAnti-oxidanten_US
dc.subjectErythrocytesen_US
dc.titleAntioxidant effect of ethanolic extract of Piper betle Linn. (Paan) on erythrocytes from patients with HbE-beta thalassemiaen_US
dc.typeArticleen_US
Appears in Collections:IJBB Vol.46(3) [June 2009]

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