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Title: Cellular AATF gene encodes a novel miRNA that can contribute to HIV-1 latency
Authors: Kaul, Deepak
Hussain, Aashiq
Keywords: miRNA;hmiR-che-1;AATF gene;Lymphocytes;AIDS
Issue Date: Jun-2009
Publisher: CSIR
Abstract: HIV-1 encoded microRNA hiv1-miR-H1 is known to induce CD4+ lymphopenia through its ability to downregulate cellular AATF gene. The present study directed to examine the target sites of this miRNA on AATF gene revealed the existence of a novel miRNA designated as hmiR-che-1 which had the inherent capacity to target HIV-1 genome especially regions coding for hiv1-miR-H1 as well as Vpr gene. Further, the expression of AATF gene coupled with its encoded microRNA hmiR-che-1 exhibited characteristic antagonism with the expression of hiv1-miR-H1 within the lymphocytes, derived from asymptomatic as well as symptomatic AIDS subjects. Based upon these observations, we propose that the widely recognised HIV-1 latency in CD4+ T-lymphocytes may arise, because of the orchestrated balance that may exist between the expression levels of hiv1-miR-H1 and hmiR-che-1 within lymphocytes infected with HIV-1
Page(s): 237-240
ISSN: 0975-0959 (Online); 0301-1208 (Print)
Appears in Collections:IJBB Vol.46(3) [June 2009]

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