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IJEB Vol.46(09) [September 2008] >


Title: Identification of amylase inhibitors from Syzygium cumini Linn seeds
Authors: Karthic, K
Kirthiram, K S
Sadasivam, S
Thayumanavan, B
Palvannan, T
Keywords: Amylase inhibitor
Diabetes mellitus
Non-competitive inhibitor
Porcine pancreatic -amylase
Syzygium cumini
Issue Date: Sep-2008
Publisher: CSIR
Abstract:  The aqueous extract of S. cumini or Eugenia jambolana seeds and Psidium guajava leaves showed higher inhibition against the porcine pancreatic -amylase among the medicinal plants studied. The -amylase inhibitors from S.cumini seeds were separated from the extract by preparative thin layer chromatography into fractions with different Rf values. The fraction with Rf value between 0.285 and 0.43, which showed maximum inhibitory activity, was eluted and analyzed through LC-MS. The compounds identified from the seed extract of S. cumini were betulinic acid and 3,5,7,4`-tetrahydroxy flavanone, which were reported earlier from S. formosanum and other plants. Dixon plot showed that the inhibition was non-competitive in nature.
Page(s): 677-680
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Source:IJEB Vol.46(09) [September 2008]

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