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Title: Synthesis and pharmacological evaluation of 3-(3,5-dimethylisoxazol-4-yl)-2-arylthiazolidin-4-ones as potential antioxidant, anti-inflammatory and analgesic agents
Authors: Marri, Srinivas
Kakkerla, Ramu
Krishna, M P S Murali
Lingabathula, Harikiran
Yellu, Narsimha Reddy
Merugu, Ramchander
Keywords: Isoxazolyl thiazolidin-4-ones;Antioxidant activity;Anti-inflammatory activity;Analgesic activity;Molecular docking studies
Issue Date: Jan-2019
Publisher: NISCAIR-CSIR, India
Abstract: 3-(3,5-Dimethylisoxazol-4-yl)-2-arylthiazolidin-4-ones 3a-l have been synthesized from 4-amino-3,5-dimethylisoxazole 1 by condensation with aromatic aldehydes, followed by cyclization with mercaptoacetic acid in excellent yields, and have been evaluated for in vitro antioxidant activity. Based on potential antioxidant property, compounds 3c, 3e, 3h, 3i, and 3l have been screened for in vivo anti-inflammatory and analgesic activity. Molecular docking studies have also been carried out to balance the bioactivity results. From these results it is evident that the compound 3c shows potential anti-inflammatory and analgesic activity.
Page(s): 109-119
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.58B(01) [January 2019]

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