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|Title:||Anti-hyperglycaemic study of Eladi Churna in streptozotocin (STZ) induced diabetic rats|
|Keywords:||Antihyperglycaemic;Diabetes mellitus;Eladi Churna;Streptozotocin|
|IPC Code:||Int. Cl.18 A61K 31/427, A61K 38/00, A61K 36/00, A61K 38/00|
|Abstract:||Diabetes mellitus is the seventh leading cause of death worldwide, with a frequent occurrence of Type II diabetes as compared to Type I. The aim of this present study was to evaluate the anti-hyperglycaemic effect of a classical herbomineral preparation Eladi Churna in STZ induced Type II diabetic rats. Thirty adult charles foster albino rats were allocated in to five groups with six animals in each group: Group I (Control Group), Group II (Diabetic control group without any medication), group III (Standard drug Glibenclamide at 1mg/kg of body weight), group IV (Eladi Churna at 300 mg/kg of body weight), group V (Eladi Churna at 600 mg/kg of body weight). Diabetes was induced by intraperitoneal injection of STZ at dose level of 35mg/kg. The whole study was conducted for 28 days. The animals were examined for blood glucose levels on 0, 7, 14, 21, 28 days respectively and other biochemical parameters such as serum cholestrol, HDL, LDL, Triglycerides, SGOT, SGPT were evaluated on day 0 and 28, respectively. The results showed that a gradual reduction in blood glucose level was assessed on administration of Eladi Churna at two different dose levels. But it was more significant at dose level of 600 mg/kg as p<0.05 with a mean±SD value of 107.34±2.67 on day 28 as compared to mean±SD value of 494.40±43.99 on day 3 (after induction of diabetes mellitus). And the results were almost analogous to potent antidiabetic drug glibenclamide with a mean±SD value of 95.44±7.44 on day 28. And the drug was also responsible for maintenance of alterations in other biochemical parameters, associated with diabetes mellitus, thus depicting its potent anti hyperglycaemic and hypolipidaemic actions.|
|ISSN:||0975-1068 (Online); 0972-5938 (Print)|
|Appears in Collections:||IJTK Vol.18(1) [January 2019]|
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