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IJEB Vol.46(08) [August 2008] >


Title: Effect of Manuka honey and sulfasalazine in combination to promote antioxidant defense system in experimentally induced ulcerative colitis model in rats
Authors: Medhi, B
Prakash, A
Avti, P K
Saikia, U N
Pandhi, P
Khanduja, K L
Keywords: Antioxidant defense system
Monuka honey
Sulfasalazine
Ulcerative colitis
Issue Date: Aug-2008
Publisher: CSIR
Abstract: Manuka honey (MH, 5g/kg) provided protection against trinitro-benzo-sulphonic acid induced colonic damage. Combination therapy (MH+sulfasalazine) also reduced colonic inflammation and all the biochemical parameters were significant compared to control and MH alone treated group. Combination therapy showed additive effect of the MH which restored lipid peroxidation and improvement of antioxidant parameters. Morphological and histological scores were significantly reduced in combination groups. In inflammatory model of colitis, oral administration of MH (5g/kg) and combination with sulfasalazine (360 mg/kg) with MH (5g/kg) significantly reduced the colonic inflammation. The results indicate the additive effect of Manuka honey with sulfasalazine in colitis.
Page(s): 583-590
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Source:IJEB Vol.46(08) [August 2008]

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