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Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.46 [2008] >
IJEB Vol.46(08) [August 2008] >
| Title: | Modulation of CYP4502E1 and oxidative stress by testosterone in liver and kidney of benzene treated rats |
| Authors: | Verma, Yeshvandra
Rana, S V S |
| Keywords: | Benzene
Castration
GSH
Kidney
Liver
Lipid peroxidation
Testosterone |
| Issue Date: | Aug-2008 |
| Publisher: | CSIR |
| Abstract: | Bilateral castration increased lipid peroxidation and consequently reduced glutathione in both liver and kidney. Testosterone administration reduced lipid peroxidation in the liver of castrated and benzene treated rats, however, reduced glutathione status could not be restored. Benzene depleted CYP4502E1 in castrated rats, however, the enzyme was restored in liver and kidney both after testosterone treatment. The results suggest that testosterone affects the metabolism and disposition of benzene by influencing CYP4502E1. Other hormonal and cellular/molecular factors may also alter the actions of testosterone. Testosterone dependent mechanism of toxicity of benzene in the liver and kidney has been discussed. |
| Page(s): | 568-572 |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.46(08) [August 2008]
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