NISCAIR Online Periodicals Repository

Research Journals >
Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.46 [2008] >
IJEB Vol.46(08) [August 2008] >

Title: Effect of Vitamin E on alcohol-induced changes in oxidative stress and expression of transcription factors NFkB and AP-1 in mice brain cerebral hemispheres
Authors: Kaur, Jasmeet
Bansal, M P
Keywords: Alcohol
Cerebral hemispheres
Vit. E
Issue Date: Aug-2008
Publisher: CSIR
Abstract: Redox sensitive transcription factors nuclear factor ĸB (NF-ĸB) and activator protein-1 are involved in the pathogenesis of alcohol-induced disorders. Because of its antioxidative properties, vitamin E may help prevent oxidative stress-induced disorders. The aim of the present study was to delineate the molecular mechanisms associated with alcohol-induced oxidative stress and to see whether vitamin E supplementation counters the alcohol-induced adverse effects. The results showed that vitamin E supplementation restored the redox status and thus prevented the alcohol-induced oxidative stress. Further measurements of the mRNA expressions of cjun, cfos, p65 (NFkB) indicated an increase in their expression during oxidative stress. Although Vit E inhibited NFkB activation, it stimulated AP1 expression. The results support the findings that alcohol induces oxidative stress in nervous tissue. The data further show that vitamin E can mitigate the toxic effects of alcohol and thus can be suitable as a potential therapeutic agent for alcohol-induced oxidative damage in brain.
Page(s): 562-567
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Source:IJEB Vol.46(08) [August 2008]

Files in This Item:

File Description SizeFormat
IJEB 46(8) 562-567.pdf160.36 kBAdobe PDFView/Open
 Current Page Visits: 805 
Recommend this item


Online Submission of Articles |  NISCAIR Website |  National Knowledge Resources Consortium |  Contact us |  Feedback

Disclaimer: NISCAIR assumes no responsibility for the statements and opinions advanced by contributors. The editorial staff in its work of examining papers received for publication is helped, in an honorary capacity, by many distinguished engineers and scientists.

CC License Except where otherwise noted, the Articles on this site are licensed under Creative Commons License: CC Attribution-Noncommercial-No Derivative Works 2.5 India

Copyright © 2015 The Council of Scientific and Industrial Research, New Delhi. All rights reserved.

Powered by DSpace Copyright © 2002-2007 MIT and Hewlett-Packard | Compliant to OAI-PMH V 2.0

Home Page Total Visits: 167520 since 01-Sep-2015  Last updated on 28-Jun-2016Webmaster: