Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/45555
Title: Bioactive metabolites from the ruminal bacterium Enterobacter amnigenus ZIH
Authors: El Euch, Imene Zendah
Shaaban, Khaled A.
Riaz, Naheed
Bahi, Muhammad
Shaaban, Mohamed
Keywords: Biological activities;Brevinic acid;Butyl-glucoside;Enterobacter amnigenus ZIH;Ruminal bacteria
Issue Date: Sep-2018
Publisher: NISCAIR-CSIR, India
IPC Code: Int. cl. (2015.01)− A6IK, A6IK 35/00, A61P 31/00
Abstract: Bioassay-guided fractionation and chromatographic purification of the crude extract of ruminal bacterium Enterobacter amnigenus ZIH (isolated from cattle) produce one new microbial product:butyl-α-D-glucopyranoside together with eleven known compounds including (S)-brevinic acid, 3-(hydroxyacetyl)-indole, Nß-acetyltryptamine, tyrosol, phenol, tryptophol, indole-3-lactic acid, uracil, adenine and two diketopiperazines cyclo-(Phe, Pro) and cyclo-(Leu, Pro). The complete NMR assignments of butyl-α-D-glucopyranoside was done - using different spectroscopic (1H, 13C, 1H-1H COSY, HMQC, and HMBC) and spectrometric methods (ESI-MS, HRESI-MS). Compounds 1a and 2 reported for the first time from a natural source. The bacterial extract exhibited high cytotoxicity against brine shrimp and moderate antimicrobial activity against a diverse set of pathogenic bacteria strains.
Page(s): 222-228
URI: http://nopr.niscair.res.in/handle/123456789/45555
ISSN: 0976-0512 (Online); 0976-0504 (Print)
Appears in Collections:IJNPR Vol.9(3) [September 2018]

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