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|Title:||Bioactive metabolites from the ruminal bacterium Enterobacter amnigenus ZIH|
|Authors:||El Euch, Imene Zendah|
Shaaban, Khaled A.
|Keywords:||Biological activities;Brevinic acid;Butyl-glucoside;Enterobacter amnigenus ZIH;Ruminal bacteria|
|IPC Code:||Int. cl. (2015.01)− A6IK, A6IK 35/00, A61P 31/00|
|Abstract:||Bioassay-guided fractionation and chromatographic purification of the crude extract of ruminal bacterium Enterobacter amnigenus ZIH (isolated from cattle) produce one new microbial product:butyl-α-D-glucopyranoside together with eleven known compounds including (S)-brevinic acid, 3-(hydroxyacetyl)-indole, Nß-acetyltryptamine, tyrosol, phenol, tryptophol, indole-3-lactic acid, uracil, adenine and two diketopiperazines cyclo-(Phe, Pro) and cyclo-(Leu, Pro). The complete NMR assignments of butyl-α-D-glucopyranoside was done - using different spectroscopic (1H, 13C, 1H-1H COSY, HMQC, and HMBC) and spectrometric methods (ESI-MS, HRESI-MS). Compounds 1a and 2 reported for the first time from a natural source. The bacterial extract exhibited high cytotoxicity against brine shrimp and moderate antimicrobial activity against a diverse set of pathogenic bacteria strains.|
|ISSN:||0976-0512 (Online); 0976-0504 (Print)|
|Appears in Collections:||IJNPR Vol.9(3) [September 2018]|
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