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Title: Facile and efficient synthesis of 1,3,4-oxadiazolyl 1,8-naphthyridines under microwave irradiation
Authors: Mogilaiah, K
Babu, H Sharath
Prasad, R Shiva
Keywords: 1,8-Naphthyridines;1,3,4-oxadiazoles;iodobenzene diacetate [PhI(OAc)2];microwave irradiation;solvent-free conditions
Issue Date: Jun-2009
Publisher: CSIR
Abstract: An efficient and convenient method for the synthesis of 1-(5-aryl-[1,3,4]-oxadiazol-2-ylmethyl)-3-(3-trifluromethyl­phenyl)-1H-[1,8]-naphthyridin-2-ones 5, by the oxidation of [2-oxo-3-(3-trifluoromethyl-phenyl)-2H-[1,8]naphthyridin-1-yl]acetic acid arylidenehydrazides 4 with iodobenzene diacetate [PhI(OAc)2] under microwave irradiation in solvent-free conditions, is described. The products are obtained in good yields and in a state of high purity. The structures of the synthesized compounds have been established on the basis of spectral and analytical data.
Page(s): 868-872
ISSN: 0376-4699
Appears in Collections:IJC-B Vol.48B(06) [June 2009]

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