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Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.48B [2009] >
IJC-B Vol.48B(06) [June 2009] >
| Title: | Synthesis leading to novel 2,4,6-trisubstituted quinazoline derivatives, their antibacterial and cytotoxic activity against THP-1, HL-60 and A375 cell lines |
| Authors: | Chandrika, P Mani
Yakaiah, T
Narsaiah, B
Sridhar, V
Venugopal, G
Rao, J Venkateshwara
Kumar, K Pranay
Murthy, U S N
Rao, A Raghu Ram |
| Keywords: | Benzoylation
acylation
cyclisation
quinazolones
quinazolines |
| Issue Date: | Jun-2009 |
| Publisher: | CSIR |
| Abstract: | A series of novel 2,4,6-trisubstituted quinazoline derivatives 6 have been synthesized from anthranilic acids 1 in five steps via benzoxazinones 2, N-benzoyl benzamides 3, quinazol-4-ones 4, 4-chloroquinazolines 5. Products 6 have been screened for antibacterial and cytotoxic activity, promising compounds have been identified. |
| Page(s): | 840-847 |
| ISSN: | 0376-4699 |
| Source: | IJC-B Vol.48B(06) [June 2009]
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