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Title: Synthesis leading to novel 2,4,6-trisubstituted quinazoline derivatives, their antibacterial and cytotoxic activity against THP-1, HL-60 and A375 cell lines
Authors: Chandrika, P Mani
Yakaiah, T
Narsaiah, B
Sridhar, V
Venugopal, G
Rao, J Venkateshwara
Kumar, K Pranay
Murthy, U S N
Rao, A Raghu Ram
Keywords: Benzoylation
Issue Date: Jun-2009
Publisher: CSIR
Abstract: <smarttagtype namespaceuri="urn:schemas-microsoft-com:office:smarttags" name="metricconverter"> A series of novel 2,4,6-trisubstituted quinazoline derivatives <b style="">6 </b>have been synthesized from anthranilic acids <b style="">1 </b>in five steps <i style="">via</i> benzoxazinones <b style="">2</b>, N-benzoyl benzamides <b style="">3</b>, quinazol-4-ones <b style="">4, </b>4<b style="">-</b>chloroquinazolines <b style="">5</b>. Products <b style="">6 </b>have been screened for antibacterial and cytotoxic activity, promising compounds have been identified. </smarttagtype>
Description: 840-847
ISSN: 0376-4699
Appears in Collections:IJC-B Vol.48B(06) [June 2009]

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