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Title: Synthesis leading to novel 2,4,6-trisubstituted quinazoline derivatives, their antibacterial and cytotoxic activity against THP-1, HL-60 and A375 cell lines
Authors: Chandrika, P Mani
Yakaiah, T
Narsaiah, B
Sridhar, V
Venugopal, G
Rao, J Venkateshwara
Kumar, K Pranay
Murthy, U S N
Rao, A Raghu Ram
Keywords: Benzoylation;acylation;cyclisation;quinazolones;quinazolines
Issue Date: Jun-2009
Publisher: CSIR
Abstract:  A series of novel 2,4,6-trisubstituted quinazoline derivatives 6 have been synthesized from anthranilic acids 1 in five steps via benzoxazinones 2, N-benzoyl benzamides 3, quinazol-4-ones 4, 4-chloroquinazolines 5. Products 6 have been screened for antibacterial and cytotoxic activity, promising compounds have been identified.
Page(s): 840-847
ISSN: 0376-4699
Appears in Collections:IJC-B Vol.48B(06) [June 2009]

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