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Title: Synthesis and antimicrobial activity of some new cyanopyridine and cyanopyrans towards Mycobacterium tuberculosis and other microorganisms
Authors: Vyas, D H
Tala, S D
Akbari, J D
Dhaduk, M F
Joshi, K A
Joshi, H S
Keywords: Cyanopyridine
antitubercular activity
antimicrobial activity
Issue Date: Jun-2009
Publisher: CSIR
Abstract: 2-Amino-3-cyano-6-(3,5-dibromo-4-methoxyphenyl)-4-aryl-pyridines 2a-i are synthesized by the reaction of compounds (2E)-3-(3,5-dibromo-4-methoxyphenyl)-1-arylprop-2-en-1-one 1a-i with malononitrile in the presence of ammonium acetate. Condensation of compounds 1a-i with malononitrile in pyridine has yielded 2-amino-3-cyano-6-(3,5-dibromo-4-methoxyphenyl)-4-arylpyrans 3a-i. The constitution of all the synthesized compounds have been established by elemental analyses, IR, 1H NMR, and mass spectral data. All the compounds are screened for their antitubercular and antimicrobial activities.
Description: 833-839
ISSN: 0376-4699
Appears in Collections:IJC-B Vol.48B(06) [June 2009]

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