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Research Journals >
Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.48B [2009] >
IJC-B Vol.48B(06) [June 2009] >
| Title: | Synthesis and antimicrobial activity of some new cyanopyridine and cyanopyrans towards Mycobacterium tuberculosis and other microorganisms |
| Authors: | Vyas, D H
Tala, S D
Akbari, J D
Dhaduk, M F
Joshi, K A
Joshi, H S |
| Keywords: | Cyanopyridine
cyanopyran
chalcone
antitubercular activity
antimicrobial activity |
| Issue Date: | Jun-2009 |
| Publisher: | CSIR |
| Abstract: | 2-Amino-3-cyano-6-(3,5-dibromo-4-methoxyphenyl)-4-aryl-pyridines 2a-i are synthesized by the reaction of compounds (2E)-3-(3,5-dibromo-4-methoxyphenyl)-1-arylprop-2-en-1-one 1a-i with malononitrile in the presence of ammonium acetate. Condensation of compounds 1a-i with malononitrile in pyridine has yielded 2-amino-3-cyano-6-(3,5-dibromo-4-methoxyphenyl)-4-arylpyrans 3a-i. The constitution of all the synthesized compounds have been established by elemental analyses, IR, 1H NMR, and mass spectral data. All the compounds are screened for their antitubercular and antimicrobial activities. |
| Page(s): | 833-839 |
| ISSN: | 0376-4699 |
| Source: | IJC-B Vol.48B(06) [June 2009]
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