Please use this identifier to cite or link to this item:
|Title:||Effect of DENA induced hepatocarcinogenesis on neuroendocrine levels in male rats|
|Authors:||Ghosh, A S|
Bhattacharyya, T K
|Abstract:||Hepatocarcinogenesis was induced in Sprague Dawley rats by injecting diethylnitrosamine (DENA); 150 mg/kg body weight, ip, a well known liver carcinogen and a mutagenic agent. Concurrent with the induction of hepatocarcinoma, psychological stress was also elicited from the changes in brain neurotransmitters. Noradrenaline and dopamine, the neurotransmitters of sympathetic system were estimated from the whole brain and corresponding hormones T<sub>3</sub>, T<sub>4</sub> and prolactin were estimated from the blood of such rats. The neuroendocrine cascade and the marker enzyme gamma glutamyl transferase were estimated at 7, 14, 21 and 30 weeks. A direct relationship between noradrenaline, T<sub>3</sub> and T<sub>4</sub> and a reciprocal relationship between dopamine and prolactin were observed, which may be correlated to the carcinogenic effect of DENA.|
|ISSN:||0975-1009 (Online); 0019-5189 (Print)|
|Appears in Collections:||IJEB Vol.46(07) [July 2008]|
Items in NOPR are protected by copyright, with all rights reserved, unless otherwise indicated.