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IJEB Vol.46(07) [July 2008] >


Title: Effect of DENA induced hepatocarcinogenesis on neuroendocrine levels in male rats
Authors: Ghosh, A S
Bhattacharyya, D
Chandra, M
Bhattacharyya, T K
Keywords: DENA
Dopamine
GGT
Male rat
Noradrenaline
Prolactin
T3
T4
Issue Date: Jul-2008
Publisher: CSIR
Abstract: Hepatocarcinogenesis was induced in Sprague Dawley rats by injecting diethylnitrosamine (DENA); 150 mg/kg body weight, ip, a well known liver carcinogen and a mutagenic agent. Concurrent with the induction of hepatocarcinoma, psychological stress was also elicited from the changes in brain neurotransmitters. Noradrenaline and dopamine, the neurotransmitters of sympathetic system were estimated from the whole brain and corresponding hormones T3, T4 and prolactin were estimated from the blood of such rats. The neuroendocrine cascade and the marker enzyme gamma glutamyl transferase were estimated at 7, 14, 21 and 30 weeks. A direct relationship between noradrenaline, T3 and T4 and a reciprocal relationship between dopamine and prolactin were observed, which may be correlated to the carcinogenic effect of DENA.
Page(s): 498-504
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Source:IJEB Vol.46(07) [July 2008]

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