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|Title:||ALDA-1 protects myocardium from reperfusion damage due to its inhibitory action on mitochondrial permeability transition|
Rodríguez-Zavala, José S
|Keywords:||ALDA-1;Calcium;Heart ischemia;Heart reperfusion;Mitochondria;Permeability transition|
|Abstract:||Reperfusion following an ischemic period represents an increased risk factor for cardiovascular morbidity and mortality. Heart reperfusion is characterized, mainly, by ventricular tachycardia, arrhythmias and a drop in blood pressure. The aim of this study was to explore the effect of the aldehyde dehydrogenase-2 agonist (ALDA-1), an inducer of the expression of the mitochondrial aldehyde dehydrogenase enzyme, on heart reperfusion damage; this is plausibly caused by the accumulation of aldehydes in the myocardium, as well as by mitochondrial permeability transition. Oxidative stress caused inhibition of cis-aconitase, increased generation of TBARs and disruption of mitochondrial DNA These adverse effects were avoided with ALDA-1 treatment.|
|ISSN:||0975-0959 (Online); 0301-1208 (Print)|
|Appears in Collections:||IJBB Vol.55(6) [December 2018]|
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