Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/45452
Title: Correlative study of serum hepcidin levels and serum iron reserve parameters in preeclampsia and HELLP syndrome
Authors: Kumar, Tapan
Zahra, Kulsoom
Dey, Tulika
Singh, Anup
Pandey, Uma
Mishra, SP
Keywords: ELISA;HELLP syndrome;Hepcidin-25;Preeclampsia;Transferrin
Issue Date: Dec-2018
Publisher: NISCAIR-CSIR, India
Abstract: HELLP syndrome is described as a special group of severe preeclampsia characterized by haemolysis (H), elevated liver enzymes (EL) and low platelets (PL), whereas preeclampsia is a disease of unknown etiology characterized by hypertension and proteinuria after the 20th week of gestation. The objective of the study was to evaluate the level of hepcidin in the serum of the patient suffering from HELLP syndrome and preeclampsia. It was done by competitive sandwich ELISA which assesses the serum level of hepcidin in the forty patients suffering from preeclampsia and HELLP syndrome (as cases) and forty healthy individuals (as control). The results of our study showed that serum hepcidin levels were significantly increased among the cases (P =0.00171) in comparison to control (P <0.05) and transferrin saturation levels were significantly decreased (P <0.05) among the cases (P =0.001) in comparison to controls. The decrease in transferrin saturation indicates that there is low serum iron level among the cases. It was concluded that increased hepcidin level may be the cause of anemia among the cases.
Page(s): 420-423
URI: http://nopr.niscair.res.in/handle/123456789/45452
ISSN: 0975-0959 (Online); 0301-1208 (Print)
Appears in Collections:IJBB Vol.55(6) [December 2018]

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