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Title: Evaluation of wound healing and anti-inflammatory activity of a Marine yellow Pigmented bacterium, Micrococcus sp.
Authors: Srilekha, V.
Krishna, G.
Seshasrinivas, V.
Singaracharya, M.A.
Keywords: Anti-inflammatory;Carrageenan;Edema;Wound healing;Wound contraction;Excision wound
Issue Date: Dec-2018
Publisher: NISCAIR-CSIR, India
Abstract: Pigmented marine bacteria were isolated from seawater collected from different coastal areas of Nellore by spread plate technique using Zobell marine agar. Among 29 pigmented bacterial isolates, the one with intense yellow pigmentation was selected for further study. Selected isolate was identified as Micrococcussp by using morphological and biochemical and molecular analysis. Pigment was extracted from bacterial pellet using methanol as a solvent and the crude yellow pigment extract was subjected to anti-inflammatory and wound healing activity. The in vivo wound healing activity was studied using excision wound model. Ointment of extract was prepared and used for assessment of wound healing activity in albino rats. Topical application of the ointment improved wound contraction when compared with control group of rats. Methanolic extract of yellow pigment reduced the carrageenan induced rat paw edema by 31.18 % on oral administration of 100 mg / kg body wt.
Page(s): 2454-2464
ISSN: 0975-1033 (Online); 0379-5136 (Print)
Appears in Collections:IJMS Vol.47(12) [December 2018]

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