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IJEB Vol.46(07) [July 2008] >


Title: Lowering of intraocular pressure by topical application of Daucus carota seed extract in rabbits
Authors: Agarwal, Renu
Gupta, S K
Srivastava, Sushma
Agrawal, S S
Saxena, Rohit
Keywords: Daucus carota
Intraocular pressure
Rabbit
Issue Date: Jul-2008
Publisher: CSIR
Abstract: In normotensive rabbits topical application of Daucus carota seed extract at the concentration of 0.3, 0.6 and 1.2% resulted in mean IOP reduction of 19.33. 23.20 and 25.61% respectively from baseline. As no significant difference was observed between the change in IOP in 0.6 and 1.2% extract treated groups, 0.6% concentration was chosen for further evaluation in rabbits with experimentally elevated IOP. In water loaded rabbits, maximum mean IOP reduction with 0.6% extract was 29.39%, which was comparable to pilocarpine. In steroid pretreated rabbits, maximum mean IOP reduction was 30.27% from baseline, which was significantly higher than pilocarpine. The extract showed a comparatively slower onset of action however, the duration of action was comparable to pilocarpine in all the experimental models.
Page(s): 541-546
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Source:IJEB Vol.46(07) [July 2008]

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