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Title: Pyrrolidinedione based macrocyclic schiff base complexes: synthesis, PXRD, antimicrobial and DNA binding studies
Authors: Sangwan, Vikas
Singh, D P
Keywords: Template methodology;Macrocycle;DNA binding;Antimicrobial;PXRD
Issue Date: Oct-2018
Publisher: NISCAIR-CSIR, India
Abstract: A collection of five macrocyclic complexes of Cd(II), Zn(II), Ni(II), Cu(II) and Co(II) have been synthesized through metal ion template [2+2] cyclocondensation of 1,8-diaminonaphthalene and pyrrolidine-2,5-dione. The newly designed metal complexes have been analyzed by various spectroscopic and physico-analytical techniques like UV-visible, elemental analysis, IR, molar conductance, ESI-MS, EPR, 1H-NMR and PXRD. The synthesized macrcocyclic metal complexes have been evaluated for their biocidal effects against some strains of pathogenic microbes. The stoichiometry of the macrocyclic complexes has been confirmed with the assistance of molar conductance, ESI-MS and elemental analysis (CHN). DNA interaction studies have been carried out for the elucidation of type and mode of binding of the complexes with the Herring fish sperm DNA. The geometry optimization has been carried out with the help of molecular mechanics using Chem 3D Ultra Software.
Page(s): 1235-1241
ISSN: 0975-0975(Online); 0376-4710(Print)
Appears in Collections:IJC-A Vol.57A(10) [October 2018]

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