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Title: Synthesis and characterization of Cu and Ag based mixed metal nanoparticle composite for antibacterial applications
Authors: Mallick, Sadhucharan
Keywords: Chitosan;Copper nanoparticles;Silver nanoparticles;Antimicrobial composite;Bactericidal;Sequential reduction method
Issue Date: Oct-2018
Publisher: NISCAIR-CSIR, India
Abstract: Iodinated mixed metal (copper, Cu and silver, Ag) nanoparticle (NPs) composite was prepared in chitosan polymeric matrix and characterized by transmission electron microscopy (TEM), X-ray diffraction (XRD), and energy dispersive X-ray analysis (EDX). The TEM analysis demonstrated that the Cu NPs and Ag NPs had an average size of 11.4 nm and 3.4 nm, respectively. Detailed antibacterial studies have been carried out on green fluorescent protein (GFP) expressing Gram-negative Escherichia coli (E. coli) bacteria. The synergistic antibacterial effect of iodinated mixed NP composite on E. coli was found to be more effective as compared to the individual components of the composite. Electron microscopic studies revealed that both Cu NPs and Ag NPs were attached to the bacterial cell wall leading to irreversible damage and eventual bacterial death.
Page(s): 1249-1256
ISSN: 0975-0975(Online); 0376-4710(Print)
Appears in Collections:IJC-A Vol.57A(10) [October 2018]

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