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|Title:||Chemical composition, antioxidant, anti-inflammatory and antitumor activities of Eucalyptus globulus Labill.|
|Authors:||Nile, Shivraj Hariram|
Keum, Young Soo
|Abstract:||Eucalyptus globulus L. is used in folk medicine throughout the world and its essential oils are widely used in modern pharmaceutical, food, and cosmetic industries. In this study, E. globulus leaves were extracted using three solvents (methanol, chloroform and hexane). The polyphenolics were quantified with HPLC and the volatiles analyzed by GC/MS with antioxidant, anti-inflammatory and antitumor activities. Results have shown a hierarchy of antioxidant and anti-inflammatory activity for three extracts as hexane > chloroform > methanol extracts with DPPH, FRAP, and oxygen radical absorbance capacity, respectively. A similar order of results was observed for antitumor activity by potato disc and colorimetric assays. The GC/MS analysis led to the identification of 1, 8-cineole (eucalyptol) as a major constituent of methanol (48.2%), chloroform (35.5%), and hexane (5.8%) extracts. Different phenolic acids (gallic acid, ellagic acid, syringic acid, and vanillic acid) and flavonoids (quercetin, rutin, and catechin) were highly abundant in methanol extract. The methanol extract of E. globulus exhibited the maximum antioxidant, anti-inflammatory, and antitumor activities. These results demonstrate E. globulus leaf extracts may be used as a potential source of bioactive compounds with remarkable antioxidant, anti-inflammatory, and antitumor activities.|
|ISSN:||0975-1009 (Online); 0019-5189 (Print)|
|Appears in Collections:||IJEB Vol.56(10) [October 2018]|
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