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|Title:||Effects of combined treatment of amiodarone and vitamin U on rat gingiva|
Turkyilmaz, Ismet Burcu
|Keywords:||Antiarrythmic drug;İnflammation;S-methylmethionine sulfonium chloride;Oral tissue;Oxidative stress|
|Abstract:||Amiodarone, the pharmaceutical drug used for the treatment of arrhythmias, is known to cause many side effects. S-Methylmethionine sulfonium is a derivative of methionine and it is widely referred to as vitamin U (Vit U). In the peer-reviewed literature, there is no study reported on the protective effects of Vit U against amiodarone’s side effects on gingiva. In this study, we investigated the oxidative and inflammatory effect of amiodarone or putative protective role of Vit U on gingiva tissue. Rats were randomly divided into four groups as follows: control group: rats received corn oil; control+Vit U treated group (50 mg/kg/day); amiodarone group (100 mg/kg/day) and amiodarone+Vit U treated group (in same dose). Amiodarone and Vit U were given orally for 7 days. Vit U was given 1 h prior to the administration of amiodarone. Gingival tissues were taken from animals and homogenized in 0.9% NaCl. Lipid peroxidation and sialic acid levels were increased significantly, glutathione levels and superoxide dismutase activities were decreased significantly in the amiodarone group when compared with the control groups. Vit U combination with amiodarone reversed these effects. These results demonstrate that administration of Vit U may have protective effects on gingiva in amiodarone treatment by decreasing oxidative stress.|
|ISSN:||0975-1009 (Online); 0019-5189 (Print)|
|Appears in Collections:||IJEB Vol.56(10) [October 2018]|
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