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Title: Anti-inflammatory activity and phenolic composition of a traditional medicinal plant from Turkey: Potentilla recta L.
Authors: Ökdem, Başak
Karatoprak, Gökçe Şeker
Koşar, Müberra
Keywords: Potentilla recta;Potentillin;LC-MS/MS;Anti-inflammatory activity
Issue Date: Oct-2018
Publisher: NISCAIR-CSIR, India
IPC Code: Int. Cl.8: A61K 36/00, A61K 9/00, A61K 38/00, A61K 39/395, A61K 45/06, A61K 36/73, A61K 31/56, A61K 31/7028, A61K 31/7032, A61K 31/7034
Abstract: Potentilla recta L. (Rosaceae) is traditionally used for its antibacterial, anti-inflammatory effects and as a tonic in Turkey. In this study, phenolic composition and anti-inflammatory activities of aerial part extract of P. recta from Turkey was examined. The chemical composition was analyzed via spectrophotometric and chromatographic (LC-MS/MS) techniques. The anti-inflammatory activity was determined by measuring the inhibitory effects on nitric oxide (NO) production and determining the levels of tumor necrosis factor alpha (TNF-α), interleukin-1 beta (IL-1β), interleukin-6 (IL-6) and interleukin-10 (IL-10) in lipopolysaccharide (LPS) stimulated RAW 264.7 cells. P. recta extract decreased the TNF-α level significantly compared to LPS group (2045.18±476.12 pg/mL).  Potentillin was identified in the extract and the extract was found to be rich in phenolic compounds. These findings support the traditional use of P. recta with its strong anti-inflammatory activities.
Page(s): 691-698
ISSN: 0975-1068 (Online); 0972-5938 (Print)
Appears in Collections:IJTK Vol.17(4) [October 2018]

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