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Title: Hepatoprotective effects of Ilex paraguariensis St. Hilaire (Yerba mate) extract in rats
Authors: Jang, Seung-Hee
Hossain, Md. Akil
Lee, Jong Suk
Reza, Md. Ahsanur
Lee, Sam-Pin
Kang, JeongWoo
Park, Seung-Chun
Keywords: Hepatoprotective activity;Antioxidant activity;Ilex paraguariensis;Yerba Mate;Oxidative stress
Issue Date: Oct-2018
Publisher: NISCAIR-CSIR, India
IPC Code: Int. Cl.8: A61K 36/00, A61P 1/16, C09K 15/00, Bo1J 19/16, A01D 7/31, A01D 7/54
Abstract: Ilex paraguariensis St. Hilaire has been revealed as an antioxidant, diuretic, hypocholesterolemic, and obesity preventive agent. The objective of the present study was to investigate the hepatoprotective effect of Ilex paraguariensis 70 % ethanol extract (IPEE) against carbon tetrachloride-induced liver injury in an animal model. IPEE (200 and 400 mg/kg/day) were administered to rats for 7 days prior to a single dose of CCl4. Organs were collected for biochemical, histological, and molecular study after 24 h of CCl4 application. Chromatographic analyses of IPEE were accomplished. The GGT, ALP, ALT and AST in CCl4-treated control were 9, 32, 401 and 168 % increased, correspondingly than in non-treated control. The SOD, GSH and GPx levels in IPEE-pre-treated rats were similar to non-toxicated control, but were seriously affected in CCl4-treated control. The IPEE pre-treatment reduced hepatic lesions and necrosis, and expressions of PPARα and CYP4A2 were recovered about 48 % by 400 mg/kg/day of IPEE-pre-treatment. We found 6 major compounds, including cynarine and chlorogenic acid, and the extract was appeared to be non-toxic in acute toxicity study. This study indicates the protective effect of IPEE against CCl4-associated liver injury by attributing its control on PPARα, CYP4A2 regulation, and thereby it could be an opportunistic agent.
Page(s): 707-715
ISSN: 0975-1068 (Online); 0972-5938 (Print)
Appears in Collections:IJTK Vol.17(4) [October 2018]

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