Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/45062
Title: In vivo antiplasmodial activities of four Nigerian plants used singly and in polyherbal combination against Plasmodium berghei infection
Authors: Celestina, Orabueze I
Sunday, Adesegun A
Duncan, Ota A
Herbert, Coker A
Keywords: Antiplasmodial;Curative activity;Suppressive activity;Polyherbal formulation;Parasitaemia;Synergistic
Issue Date: Oct-2018
Publisher: NISCAIR-CSIR, India
IPC Code: Int. Cl.8: A61K 36/00, A01D 20/46, A61K 39/00, A61K 31/47, A61K 31/4706, A61K 31/357
Abstract: Methanolic extracts from 4 medicinal plants representing 4 families, used traditionally for malaria treatment in South east Nigeria were screened for their in vivo antimalarial activity in mice against a chloroquine (CQ)-sensitive Plasmodium berghei NK65, alone and in combination as polyherbal remedy. The methanolic extracts of individual plants in single and in combination (100-400 mg kg-1) were administered orally to P. berghei-infected mice in both early and established models of antiplasmodial studies. Survival time was determined. When used alone, extracts from the 4 plants, Fadogia cienkowskii (FC), Lophira lanceolata (LL), Vernonia conferta (VC) and Protea madiensis (PM) had statistically significant parasitaemia suppression (62.06 – 93.44 %) and curative (48.93 – 72.47 %) effects. Lower doses of the 4 individual plants constituted FLVP at a combination ratio of 1: 1: 1: 1. Polyherbal formulation (FLVP) gave statistically significant suppression and curative which ranged from 45.5 – 85.1 % and 45.5 – 74.00 %, respectively. A more general improved antimalarial recovery effect, controlled weight lost and enhanced survival rate of the test mice compared to the individual plant therapeutic effect was observed. The standard drug, CQ gave stronger curative effect 100 % parasitaemia clearance. Our study findings suggest that the 4 plants used both as monotherapy and combined polyherbal remedy showed antiplasmodial in vivo activities and FLVP showed a more stable recovery status. FLVP is safe up to tested dose of 4000 mg kg-1. Further studies using varying fixed ratios for FLVP could result in better and improved antimalarial formulation.
Page(s): 716-723
URI: http://nopr.niscair.res.in/handle/123456789/45062
ISSN: 0975-1068 (Online); 0972-5938 (Print)
Appears in Collections:IJTK Vol.17(4) [October 2018]

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