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Title: Anti-obesity potential of Medohar Ark: A traditional Ayurvedic preparation in high fat diet-induced rat model
Authors: Laturiya, Akash A
Parmar, Komal M
Prasad, Satyendra K
Bhojraj, Nandini
Itankar, Prakash R
Keywords: Crocus sativus L.;Crocin;Medohar Ark;Obesity;Lipid profile
Issue Date: Oct-2018
Publisher: NISCAIR-CSIR, India
IPC Code: Int. Cl.8: A61K 36/00, A01D 20/25, A61K 31/00, A23P 10/35, G01N 33/92
Abstract: The aim of the present study was to develop a phytochemical profile of Medohar Ark, one of the Ayurvedic formulation used as a potent tool for reducing weight in obese patients and also to perform preclinical evaluation for anti-obesity activity. The physicochemical parameters such as pH, viscosity, specific gravity and total solid content of Medohar Ark marketed (MAM), Medohar Ark in-house (MAIH) and distilled cow urine (DCU) were performed along with phytochemical screening and chromatographic (HPTLC and HPLC) study using Crocin as a biomarker. Phytochemical screening revealed the presence of alkaloids, flavonoids, tannins, sterol, carbohydrates and saponins in MAIH and MAM. The HPTLC analysis revealed that, MAIH contained 4.58 % w/w of Crocin, whereas in MAM, Crocin was not detected. However, HPLC analysis of MAIH and MAM showed that MAIH and MAM contained 4.56 % w/w and 1.23 % w/w of crocin, respectively. The pharmacological evaluation concluded that, MAIH showed better result as compared to MAM in reduction of body weight of rats in high fat diet (HFD) rat model. From the lipid profile and antioxidant evaluations of animals, it was observed that there was a significant restoration in altered lipid profile and antioxidant status of HFD induced rats treated with MAM and MAIH, which was also confirmed through histopathological studies showing very less fat deposition. The overall study concludes that the Medohar Ark has a significant anti-obesity activity especially in case of in-house formulation, which can be used as a major tool for obesity management in human healthcare.
Page(s): 745-753
ISSN: 0975-1068 (Online); 0972-5938 (Print)
Appears in Collections:IJTK Vol.17(4) [October 2018]

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