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Title: Antibacterial activity of Marchantia papillata Raddi subsp. grossibarba (Steph.) Bischl. against Staphylococcus aureus
Authors: Negi, Kavita
Tewari, SD
Chaturvedi, Preeti
Keywords: Antibacterial;Staphylococcus aureus;Staphylococcus aureus;M. palmata;Riccardin C;Bhotia;Raji;Tharus;Boxas;Khamti tribes
Issue Date: Oct-2018
Publisher: NISCAIR-CSIR, India
IPC Code: Int. Cl.8: A61K 36/00, A61K 36/10, A61K 39/40, A61K 39/02, A61K 39/116, C12R 1/445
Abstract: Staphylococcus aureus is a universally identified gram positive bacteria causing boils, carbuncles, skin infections or abscess, involving muscle or bone, and can easily disseminate even to the lungs or affect heart valves. The prolonged use of synthetic drugs like methicillin and cephalosporin have led to development of resistance in S. aureus. The present study aims to search for a natural and potent antimicrobial agent by validating the use of some traditionally used Bryophytes applying standard antimicrobial assays along with chemical characterization of important antibacterial compounds. Crude methanol/ethanol and acetone extracts of six Bryophyte species; collected from different regions of Kumaon hills (belonging to five different families), viz. Conocephalum conicum (L.) Underw, Marchantia papillata Raddi subsp. grossibarba (Steph.) Bischl. (syn. Marchantia palmata Reinw., Nees & Blume), Reboulia hemispherica L. Raddi, Asterella wallichiana (Lehm.) Grolle, Anaectangium thomsonii Mitt. and Funaria hygrometrica Hedw; were prepared and screened for antibacterial activities by determining minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC). The experiment showed that the six Bryophyte species had significant antibacterial activities against S. aureus with MIC and MBC ranging from 0.97 to 31.25 µg/mL and 1.95 to 125 µg/mL, respectively. Ethanol extract of M. papillata showed highest zone of inhibition (ZI=31±0.57 mm) with 0.97 µg/mL MIC and 1.95 µg/mL MBC and the ZI of its ethanol extract was found superior over the ZI of used antibiotics, viz. streptomycin and choloramphenicol. GC-MS data obtained from its ethanol extract showed a high percentage of sesquiterpenes/diterpenes (8.18 %), steroids (11.52 %), fatty acids (31.77 %) and alcohol derivatives (1.46 %) attributing to its antibacterial potential. Besides, a specific marker compound of liverwort-riccardin C (2.46 %), was also detected in M. papillata.
Page(s): 763-769
ISSN: 0975-1068 (Online); 0972-5938 (Print)
Appears in Collections:IJTK Vol.17(4) [October 2018]

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