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Title: Anti HIV-1 activity, anti bacterial activity and phytochemical analysis of leaf extracts from Cleistanthus collinus (Roxb.) Benth. ex Hook.f.
Authors: Mohanraj, Remya
Haidar, Shoaib
Nobre, Malcolm
Anantan, R
Keywords: Cleistanthus collinus;Anti- HIV 1;p24 antigen expression;HPLC;Antibacterial activity;Phytochemicals;Lymphocyte culture
Issue Date: Oct-2018
Publisher: NISCAIR-CSIR, India
IPC Code: Int. Cl.8: A61K 36/00, A61K 38/26, A61P 31/18, C07K 14/16, A01D 10/00, C07K 14/155, A61P 31/04, C07, C08, C12, A61K 39/02, A61K 39/015, A61K 39/116, A61K 39/008, A61K 39/00, C12N 5/20, C12N 5/24
Abstract: This study is an attempt to identify new chemical entities with anti HIV1 activity. In vitro anti-HIV activity of Cleistanthus collinus extracts was evaluated using the p24 antigen assay. A dose-dependent inhibition of the p24 antigen expression was observed and the extract was found to be efficient against HIV-1. Antibacterial activity was tested against four different bacteria employing the agar well diffusion method and the highest activity was exhibited by the chloroform and methanolic extracts of C. collinus. HPLC analysis of the crude extract revealed the presence of phytochemicals like Gallic acid, Chlorogenic acid, 3,4 Dihydroxy B-acid, Diadizin, p-Coumaric acid, Epi-GC Gallate, Ellagic acid, Luteoline, Hesperitin and Quercetin. This report on the anti HIV 1 activity of C. collinus and the results obtained from the present study suggest that the extracts could serve as a source for providing potential lead compound for drug discovery against HIV-1.
Page(s): 770-775
ISSN: 0975-1068 (Online); 0972-5938 (Print)
Appears in Collections:IJTK Vol.17(4) [October 2018]

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