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|Title:||Potential herb-drug interaction of a flavone glycoside from Cuminum cyminum: Possible pathway for bioenhancement of rifampicin|
Satti, Naresh K
Bhusari, Sachin S.
|Keywords:||Cuminum cyminum;Flavone glycoside;Pharmacokinetic interaction;Bioenhancer;Herb-drug interaction|
|IPC Code:||Int. Cl.8: A61K 36/00, C07D 311/30, A01N, A01D 11/14, A61P 31/06, A61K 39/395, A61K 47/48, A61K 38/00, A61K 45/06, A61K 47/48|
|Abstract:||Traditional knowledge on classical herbal based Ayurvedic formulation namely ‘Trikatu’ in the Indian system of medicine has led to the discovery of ‘Risorine’, a world’s first boosted rifampicin in combination with piperine (one of ingredient in Trikatu) as bioenhancer for the treatment of tuberculosis. This encourages us to combine rifampicin with a flavone glycoside (CC-I), one of ingredient of Cuminum cyminum which found its application in culinary purposes and immensely widespread in diverse ethnomedical systems worldwide as an integral part of folklore therapy. Therefore, aim of the study is to explore the reason for bioenhancement of rifampicin by CC-I using a panel of in vitro and in vivo experimentations for the first time. Plasma concentration of rifampicin was markedly enhanced by CC-I orally in Wistar rats. Mechanistic studies showed that CC-I have action on efflux transporters based on rhodamine transport and P-glycoprotein dependent ATPase assay but no alteration of in vitro transcellular diffusion and plasma protein binding of rifampicin. Intestinal transit of rat was not affected upon treatment with CC-I whereas inhibition of CYP3A4 in rat and human liver microsomes was occurred to a little extent. Bioenhancer effect of CC-I was mainly through improving absorption by down regulation of efflux transporters.|
|ISSN:||0975-1068 (Online); 0972-5938 (Print)|
|Appears in Collections:||IJTK Vol.17(4) [October 2018]|
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