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|Title:||The practical, efficient, diastereoselective synthesis of (3R,1ʹS)-3-[(1ʹ-N-methylamino)ethyl]pyrrolidine: A chiral side chain unit for quinolone type anti-fungal agents|
|Keywords:||N-Methylaminoethylpyrrolidine;Quinolone type anti-fungal agents;Chiral building block;Diasteroselective hydrogenation;Ru-BINAP complex catalyst|
|Abstract:||(3R, 1ʹS)-3-[(1ʹ-N-Methylamino)ethyl]pyrrolidine 1, which is an important chiral building block, has been synthesized from 3-acetyl-1-benzyl-2-pyrrolidione 5 by diasteroselective hydrogenation using the Ru-BINAP complex as the key step, followed by hydride reduction, methanesulfonylation, inverse amination and debenzylation.|
|Appears in Collections:||IJC-B Vol.57B(09) [September 2018]|
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