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Title: The practical, efficient, diastereoselective synthesis of (3R,1ʹS)-3-[(1ʹ-N-methylamino)ethyl]pyrrolidine: A chiral side chain unit for quinolone type anti-fungal agents
Authors: Yuasa, Yoshifumi
Keywords: N-Methylaminoethylpyrrolidine;Quinolone type anti-fungal agents;Chiral building block;Diasteroselective hydrogenation;Ru-BINAP complex catalyst
Issue Date: Sep-2018
Publisher: NISCAIR-CSIR, India
Abstract: (3R, 1ʹS)-3-[(1ʹ-N-Methylamino)ethyl]pyrrolidine 1, which is an important chiral building block, has been synthesized from 3-acetyl-1-benzyl-2-pyrrolidione 5 by diasteroselective hydrogenation using the Ru-BINAP complex as the key step, followed by hydride reduction, methanesulfonylation, inverse amination and debenzylation.
Page(s): 1189-1193
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.57B(09) [September 2018]

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