Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/45043
Title: A convenient synthesis of enantiomerically pure α-isocyano esters and Nβ-Fmoc-amino alkyl isonitriles derived from α-amino acids employing PPh3/I2 under mild conditions
Authors: Santhosh, L
Shekharappa
Krishnamurthy, M
Sureshbabu, Vommina V
Keywords: N-Formyl amino acid esters;Dehydration;α-isocyano esters;N-Fmoc-β-amino alkyl isonitiles;α-amino acids
Issue Date: Sep-2018
Publisher: NISCAIR-CSIR, India
Abstract: Synthesis of enantiomerically pure α-isocyano esters has been described starting from α-amino acids. The end products are obtained in good yields by dehydration of N-formyl amino acid esters using PPh3/I2 in the presence of NMM in CH2Cl2 at −15 to 0°C within 1 h. The protocol has been further extended to obtain N-Fmoc-β-amino alkylisonitiles 4j-l, which were isolated as stable solids, purified and fully characterized by mass, 1H and 13C NMR analysis.
Page(s): 1203-1207
URI: http://nopr.niscair.res.in/handle/123456789/45043
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.57B(09) [September 2018]

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