Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/4503
Full metadata record
DC FieldValueLanguage
dc.contributor.authorGupta, Girdhari Lal-
dc.contributor.authorRana, Avtar Chand-
dc.date.accessioned2009-06-05T10:02:30Z-
dc.date.available2009-06-05T10:02:30Z-
dc.date.issued2008-06-
dc.identifier.issn0975-1009 (Online); 0019-5189 (Print)-
dc.identifier.urihttp://hdl.handle.net/123456789/4503-
dc.description470-475en_US
dc.description.abstractWithania somnifera (WS) or its psychotropic preparation is known to play a critical role in morphine, alcohol and benzodiazepines addiction. This study investigates the role of WS in acute ethanol and withdrawal from chronic ethanol consumption using elevated plus maze paradigm in rats. Acute administration of ethanol (1.5-2 g/kg, ip) triggered anxiolytic effect and withdrawal from prolonged ethanol (9% v/v ethanol, 15 days) consumption elicited enhanced behavioral despair (anxiety). Acute administration of WS (50 mg/kg, oral) potentiated the anxiolytic action of subeffective dose of ethanol (0.5 or 1 g/kg, ip). Moreover, the ethanol withdrawal anxiety was markedly antagonized in dose dependent manner by WS at 200 and 500 mg/kg or higher dose of ethanol (2.5 g/kg). However, co-administration of subeffective doses of WS (50 mg/kg, oral) and ethanol also attenuated withdrawal-induced anxiety due to chronic ethanol (9% v/v ethanol, 15 days) consumption. The results suggest the protective effect of WS in the management of ethanol withdrawal reactions.en_US
dc.language.isoen_USen_US
dc.publisherCSIRen_US
dc.sourceIJEB Vol.46(06) [June 2008]en_US
dc.subjectElevated plus mazeen_US
dc.subjectEthanolen_US
dc.subjectWithania somniferaen_US
dc.subjectWithdrawal anxietyen_US
dc.titleEffect of Withania somnifera Dunal in ethanol-induced anxiolysis and withdrawal anxiety in ratsen_US
dc.typeArticleen_US
Appears in Collections:IJEB Vol.46(06) [June 2008]

Files in This Item:
File Description SizeFormat 
IJEB 46(6) 470-475.pdf50.46 kBAdobe PDFView/Open


Items in NOPR are protected by copyright, with all rights reserved, unless otherwise indicated.